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Yes, as long as voltages do not exceed the single ended range (this is 5 volts on a Prologger). To measure the 50mV differential you must specify 0 to 50 mV as the differential voltage range of tranducer used by the channel. This can be done as follows:
Open the scheme you are using with Scheme Editor.
Select "Window" then "Instruments" then "View" to view the instruments installed in the scheme.
Double click the instrument whose transducer definition you wish to edit, this will display a list of transducers making up the instrument.
Double click the transducer whose definition you wish to edit.
To configure the transducer to accept Differential inputs, click the green drop down arrow adjacent to the "Output" field and select "Diff. Voltage" from the available options. This will configure the analog channel specified in the "Channel" field for differential input.
To configure the range of the differential channel enter the minimum channel value in the "MIN:" field e.g 0. Enter the maximum channel value in the "MAX:" field e.g 50 (0 to 50 mV).
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